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doi: 10.3389/fpubh.2024.1519623 88 IkedaM.EnomotoN.HashimotoD.FujisawaT.InuiN.NakamuraY.et al
It contains L-Carnitine L-Tartrate, which plays a key role in fatty acid metabolism by transporting long-chain fatty acids into mitochondria for energy production, thereby improving stamina, muscle recovery, and cardiovascular function
This is achieved by alleviating the inhibition of carnitine palmitoyltransferase 1 (CPT1), which is mediated by the local production of malonyl-CoA at the outer membrane of the mitochondria, via ACC2
PMID: 297 GongZHuQSabaghZLiangTHeC
In Phase 2 trials, retatrutide produced approximately 24% mean weight loss at 48 weeks at 12 mg, compared with about 22.5% for tirzepatide at 15 mg in the SURMOUNT-1 trial though direct head-to-head data is not yet available
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